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Target intelligence / Profile preview
Tumor necrosis factor receptor superfamily member 13B (TACI)
- Target
- TACI
- Molecular classification
- Receptor, Tumor Necrosis Factor Receptor Superfamily
01
Overview
Tumor necrosis factor receptor superfamily member 13B (TACI) is a transmembrane receptor primarily expressed on B cells. It plays a crucial role in regulating B cell survival, maturation, and antibody production through interactions with its ligands BAFF and APRIL. Mutations in TACI are associated with immunodeficiency disorders like CVID and IgA deficiency, potentially leading to autoimmunity or cancer risk.
- Other names
- CD267IGAD2TR13B_HUMANtumor necrosis factor receptor 13BTNFRSF13B
02
Mechanism of action
Modulation of B cell signaling pathways (NFAT, AP-1, NF-κB) through ligand binding (BAFF, APRIL)
03
Biological functions
B cell survivalB cell maturationB cell homeostasisAntibody productionClass-switch recombinationImmune response
04
Disease associations
Common Variable Immunodeficiency Disorder (CVID)Selective IgA deficiencyAutoimmunityCancerInfection
05
Safety considerations
Potential for immune dysregulation leading to autoimmunity or increased cancer riskIncreased susceptibility to infections due to impaired antibody production
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