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Target intelligence / Profile preview
Tumor Necrosis Factor Receptor Superfamily Member 19 (None)
- Target
- None
- Molecular classification
- Receptor, Tumor necrosis factor receptor superfamily
01
Overview
Tumor necrosis factor receptor superfamily member 19 (TNFRSF19), also known as TROY, is a type I transmembrane receptor highly expressed during embryonic development. It interacts with members of the TNF receptor-associated factor (TRAF) family and can activate the c-Jun N-terminal kinase (JNK) signaling pathway, leading to apoptosis. The receptor plays an essential role in embryonic development and has been implicated in regulating cell fate decisions such as proliferation, differentiation, and survival. Its expression is regulated by Wnt signaling pathways; upregulation promotes osteogenesis while downregulation favors adipogenesis. High expression has been linked to nasopharyngeal carcinoma progression.
- Other names
- TNFRSF19TROYTAJTAJ-alphaTRADE
02
Biological functions
Developmental regulationApoptosis inductionStem cell fate determinationCell differentiationCell proliferationSignal transduction
03
Disease associations
Ovarian cancerCongenital myopathy 12Nasopharyngeal carcinoma
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