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Target intelligence / Profile preview
Tumor necrosis factor receptor superfamily member 1A (TNFR1)
- Target
- TNFR1
- Molecular classification
- Receptor, Tumor Necrosis Factor Receptor Superfamily
01
Overview
Tumor necrosis factor receptor superfamily member 1A (TNFR1) is a type I transmembrane protein that belongs to the TNFR superfamily. It is constitutively expressed on most nucleated cells and plays a crucial role in mediating the effects of TNFα, a key cytokine involved in inflammation and immunity. Upon TNFα binding, TNFR1 initiates several signaling pathways, including NF-κB activation, apoptosis, and necroptosis, influencing cell survival, proliferation, and death. Due to its central role in inflammation and cell fate regulation, TNFR1 is a target for therapeutic intervention in various diseases.
- Other names
- TNFRSF1ACD120a
02
Mechanism of action
TNFα antagonist; Modulation of NF-κB, apoptosis, and necroptosis pathways
03
Biological functions
Signal transductionInflammation regulationCell survivalApoptosisNecroptosisImmune response
04
Disease associations
Tumor Necrosis Factor Receptor Associated Periodic Syndrome (TRAPS)Multiple sclerosisSchizophreniaBipolar disorderDementiaAutoimmune diseasesCancersInflammatory disorders
05
Safety considerations
Potential for immunosuppressionIncreased risk of infectionExacerbation of certain autoimmune conditions
06
Biomarkers
Serum TNFR1 levels in schizophrenia and bipolar disorderSerum TNFR1 levels in cognitive impairment and dementia
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