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Target intelligence / Profile preview
Tumor Necrosis Factor Receptor Superfamily Member 1B (TNFR2)
- Target
- TNFR2
- Molecular classification
- Receptor, Tumor Necrosis Factor Receptor Superfamily
01
Overview
Tumor necrosis factor receptor superfamily member 1B (TNFR2) is a receptor for tumor necrosis factor-alpha (TNFα), a key cytokine in inflammation and immune regulation. Unlike TNFR1, TNFR2 expression is restricted and primarily found on immune cell subsets. TNFR2 lacks a death domain and signals through TRAF proteins to activate NFκB pathways, promoting cell survival and proliferation. TNFR2 plays complex roles in cancer, acting both pro-tumorigenically by supporting immunosuppressive cells and anti-tumorigenically by activating cytotoxic T-cells. It is also implicated in neuroprotection.
- Other names
- TNFRSF1BCD120b
02
Mechanism of action
Agonism or antagonism of TNFR2 signaling pathways
03
Biological functions
Immune regulationSignal transductionCell survivalCell proliferationActivation of NFκB pathwayNeuroprotectionCostimulation
04
Disease associations
CancerInflammationNeurodegenerative diseaseImmune disorders
05
Safety considerations
Potential for immune suppressionContext-dependent pro-tumorigenic or anti-tumorigenic effectsPotential for off-target effects due to TNFα involvement in multiple pathways
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