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Target intelligence / Profile preview
Tumor Necrosis Factor Receptor Superfamily Member 25 (TNFRSF25)
- Target
- TNFRSF25
- Molecular classification
- Receptor, Type I transmembrane protein, Tumor necrosis factor receptor superfamily
01
Overview
Tumor Necrosis Factor Receptor Superfamily Member 25 (TNFRSF25), also known as DR3, is a type I transmembrane glycoprotein and a member of the TNF receptor superfamily. It is primarily expressed on activated T lymphocytes, FoxP3+ regulatory T cells, and other immune cells. Its only known ligand is TL1A, which is produced by antigen-presenting cells. Upon binding TL1A, DR3 can activate NF-kappaB signaling, leading to increased IL-2 responsiveness and proliferation of T cells, or it can trigger apoptosis through the FADD/caspase cascade. DR3 plays a role in immune regulation, lymphocyte homeostasis, and is implicated in the pathogenesis of autoimmune diseases and inflammatory bowel disease.
- Other names
- DR3APO-3TRAMPWSL-1TR3LARD
02
Mechanism of action
Binding to TL1A activates NF-kappaB or apoptosis pathways depending on cell context.
03
Biological functions
Signal transductionApoptosisImmune responseCell proliferationCell deathCo-stimulationCytokine regulation
04
Disease associations
Autoimmune diseasesInflammatory bowel diseaseLymphocyte homeostasis dysregulation
05
Safety considerations
Potential for dysregulation of immune responsesPotential for unintended apoptosis or cell proliferation effects
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