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Target intelligence / Profile preview
Tumor Necrosis Factor Receptor Superfamily Member 3 (TNFRSF3)
- Target
- TNFRSF3
- Molecular classification
- Receptor, Transmembrane protein, TNF receptor superfamily
01
Overview
Tumor necrosis factor receptor superfamily member 3 (TNFRSF3), also known as lymphotoxin beta receptor (LTβR), is a cell surface transmembrane protein that belongs to the tumor necrosis factor receptor superfamily. It primarily functions as a receptor for the heterotrimeric lymphotoxin complex containing lymphotoxin-alpha and lymphotoxin-beta, as well as for the ligand LIGHT/TNFSF14. LTβR is essential for the development and organization of secondary lymphoid organs and plays a role in apoptosis, cytokine release, and hepatic diseases.
- Other names
- Lymphotoxin beta receptorLTBRLTβRTNF receptor type IIITNF RIIITNF Rrp
02
Biological functions
Immune organogenesisApoptosis inductionCytokine releaseNF-kappaB signalingImmune responseSignal transduction
03
Disease associations
Lymphoid tissue development disordersHepatic diseasesHepatitisHepatocellular carcinomaInflammation
04
Safety considerations
Potential for immune-related adverse events due to its role in immune organogenesis and signaling.Dysregulation can lead to lymphoid tissue disorders.
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