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Target intelligence / Profile preview
Tumor Necrosis Factor Receptor Superfamily Member 9 Ligand (4‑1BBL)
- Target
- 4‑1BBL
- Molecular classification
- Cytokine, Type II transmembrane glycoprotein, Tumor Necrosis Factor Ligand Superfamily
01
Overview
Tumor necrosis factor receptor superfamily member 9 ligand (4-1BBL), also known as CD137L or TNFSF9, is a type II transmembrane glycoprotein belonging to the TNF ligand superfamily. It is expressed primarily on antigen-presenting cells (APCs) and some carcinoma cell lines. 4-1BBL binds to its receptor 4-1BB (CD137) on T lymphocytes, acting as a costimulatory molecule to enhance T cell activation, survival, and proliferation. This interaction plays a crucial role in regulating immune responses, particularly in cytotoxic CD8+ T cell activity. Agonists targeting the 4-1BBL/4-1BB pathway are being investigated for cancer immunotherapy due to their ability to boost anti-tumor immunity.
- Other names
- CD137LTNFSF9TNFLG5A
02
Mechanism of action
Agonists targeting 4-1BB increase T cell activation.
03
Biological functions
Costimulation of T cell activationEnhancement of T cell survivalPromotion of T cell proliferationActivation of anergic T lymphocytesRegulation of cytotoxic CD8+ T cell responsesBidirectional signal transductionImmune response
04
Disease associations
CancerImmunodeficiency 16Mouth DiseaseImmune modulation
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