Tumor necrosis factor receptor type 1-associated death domain protein (TRADD)

Tumor necrosis factor receptor type 1-associated death domain protein (TRADD) is a cytoplasmic adaptor protein that plays a central role in transducing signals from members of the tumor necrosis factor receptor superfamily, especially TNFR1. TRADD contains a C-terminal death domain that interacts with the death domains of activated receptors, as well as other apoptosis- and signaling-related proteins such as FADD, RIPK1, and TRAF2. Upon receptor activation, TRADD acts as a molecular platform, recruiting and organizing downstream effectors that regulate major cellular outcomes: activation of NF-κB (promoting cell survival and inflammatory responses), or induction of apoptosis via caspase activation. TRADD is required for both apoptotic and non-apoptotic TNF signaling, and participates in multiple receptor pathways including TNFR1, Fas, DR3, DR4/5, DR6, p75NTR, TLR3, and TLR4. Pathological alterations in TRADD signaling have been linked to disorders of cell death and inflammation, including cancer, chronic inflammatory diseases, and neurodegeneration[1][2][3][5][8].

Other names

TNFRSF1A-associated via death domainTNFR1-associated death domain proteinTumor necrosis factor receptor-1-associated proteinTRADDHs.89862

Disruption or inhibition of TRADD recruitment to TNF family receptors to modulate apoptotic or NF-κB signaling[1][2]. Modulation of TRADD interactions to control downstream signaling those leading to cell death or survival[1][7].