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Target intelligence / Profile preview
Tumor Necrosis Factor Receptor Type 2 (TNFR2)
- Target
- TNFR2
- Molecular classification
- Receptor, Tumor Necrosis Factor Receptor Superfamily, Type I transmembrane protein
01
Overview
Tumor Necrosis Factor Receptor Type 2 (TNFR2) is a type I transmembrane protein and a member of the tumor necrosis factor receptor superfamily. It is one of two main receptors for TNFα. TNFR2 plays a role in immune regulation, tissue protection, and can have both pro-inflammatory and anti-inflammatory effects depending on the context. It is highly expressed on myeloid cells, Tregs, and some T-cell/B-cell subsets. TNFR2 is being investigated as a therapeutic target in cancer immunotherapy and autoimmune diseases.
- Other names
- Tumor necrosis factor receptor superfamily member 1BTNFRSF1BCD120b
02
Mechanism of action
Agonism or antagonism of TNFR2 signaling, modulation of immune cell activity, tissue protection
03
Biological functions
Signal transductionImmune regulationTreg activation/expansionMyeloid-derived suppressor cell activation/expansionTissue protectionNFκB activationApoptosis (indirectly)Cell survival
04
Disease associations
CancerAutoimmune diseasesInflammationMultiple sclerosisHeart failure
05
Safety considerations
Potential for broad immunosuppressionExacerbation of certain inflammatory conditionsOff-target effects on other TNFRSF members
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