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Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)
- Target
- TRAIL
- Molecular classification
- Cytokine, Tumor Necrosis Factor Superfamily, Ligand
01
Overview
Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) is a cytokine that induces selective tumor cell death through activation of the extrinsic apoptotic cascade via binding to pro-death receptors DR4/TRAIL-R1 & DR5/TRAIL-R2. Decoy receptors DcR1/TRAIL-R3 & DcR2/TRAIL-R4 act as negative regulators. Signaling is primarily pro-apoptotic but can trigger non-canonical survival/motility pathways depending on context. It is an attractive anticancer target due to selectivity; however, clinical translation has been challenged by resistance mechanisms.
- Other names
- Apo2LCD253TNFSF10
02
Mechanism of action
Activation of extrinsic apoptotic cascade via binding to pro-death receptors DR4/TRAIL-R1 & DR5/TRAIL-R2.
03
Biological functions
ApoptosisImmune responseCell deathSignal transduction
04
Disease associations
Cancer
05
Safety considerations
Resistance mechanismsActivation of survival pathwaysPotential for promoting motility/metastasisLimited clinical efficacy
06
Interacting drugs
Recombinant human TRAIL proteins
3 more in the full profile.
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