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Target intelligence / Profile preview
Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor 2 (DR5)
- Target
- DR5
- Molecular classification
- TNF Receptor Superfamily, Receptor
01
Overview
Tumor necrosis factor-related apoptosis-inducing ligand receptor 2 (DR5) is a key mediator of programmed cell death via interaction with its cognate ligand TRAIL. Its selective pro-apoptotic activity against tumor cells makes it an attractive target for anticancer therapies—though challenges remain regarding resistance mechanisms within certain malignancies.
- Other names
- TRAILR2TNFRSF10BKILLER/DR5
02
Mechanism of action
DR5 agonists induce apoptosis by binding to DR5, leading to receptor oligomerization, recruitment of FADD and caspase-8/10, and activation of the caspase cascade.
03
Biological functions
ApoptosisSignal transductionImmune responseCell deathNF-kappaB signaling
04
Disease associations
Cancer
05
Safety considerations
Resistance mechanisms within tumorsPotential off-target effectsSystemic toxicityLimited clinical efficacy
06
Interacting drugs
Recombinant human TRAIL variants
1 more in the full profile.
07
Biomarkers
DR5 expression levels in tumor tissue
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