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Target intelligence / Profile preview
Tumor necrosis factor-stimulated gene-6 (TSG-6)
- Target
- TSG-6
- Molecular classification
- Link module superfamily, Secreted protein
01
Overview
Tumor necrosis factor-stimulated gene-6 (TSG-6) is a secreted protein that is upregulated in response to proinflammatory mediators. It has anti-inflammatory and chondroprotective effects, acting as part of a negative feedback loop that downregulates excessive inflammation. TSG-6 binds hyaluronan, a key extracellular matrix component, and interacts with inter-alpha-inhibitor proteins, enhancing their anti-protease activity, contributing to tissue protection during inflammation. It plays a role in various biological processes including ovulation.
- Other names
- TNFAIP6
02
Mechanism of action
Modulates inflammation by binding hyaluronan and interacting with inter-alpha-inhibitor proteins, leading to decreased inflammation and tissue protection.
03
Biological functions
Anti-inflammatoryExtracellular matrix remodelingHyaluronan bindingInter-alpha-inhibitor protein interactionChondroprotection
04
Disease associations
InflammationArthritisCancerOvulation disordersTissue injury
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