Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Tumor Necrosis Factor-like Cytokine 1A (TL1A)
- Target
- TL1A
- Molecular classification
- Type II transmembrane protein, Tumor Necrosis Factor (TNF) superfamily ligand
01
Overview
Tumor Necrosis Factor-like Cytokine 1A (TL1A), also known as TNFSF15, is a type II transmembrane protein belonging to the TNF superfamily. It exists as both membrane-bound and soluble forms and plays a critical role in immune regulation, influencing the proliferation, activation, differentiation, and apoptosis of immune cells. TL1A signals primarily through its receptor DR3/TNFRSF25, activating MAPK, NF-kB, and caspase-dependent pathways. It is implicated in various autoimmune and inflammatory diseases, including IBD, rheumatoid arthritis, and asthma, making it a therapeutic target. Anti-TL1A antibodies are under clinical investigation as potential treatments for these conditions.
- Other names
- TNFSF15Tumor necrosis factor superfamily member 15
02
Mechanism of action
Monoclonal antibody therapies blocking TL1A pathway
03
Biological functions
Immune regulationCell proliferationApoptosisCytokine productionT cell differentiationNF-kB pathway activationMAPK pathway activationCaspase-dependent pathway activation
04
Disease associations
Inflammatory bowel disease (IBD)Rheumatoid arthritisPsoriatic arthritisAnkylosing spondylitisAsthmaAutoimmune diseasesInflammatory diseases
05
Safety considerations
Potential for immunosuppressionClinical trial data still emerging
06
Interacting drugs
Anti-TL1A antibodies
07
Biomarkers
Elevated levels of soluble TL1A (sTL1A) in serum/body fluids
Beyond the preview
Go deeper on Tumor Necrosis Factor-like Cytokine 1A (TL1A).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Tumor Necrosis Factor-like Cytokine 1A (TL1A).