Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Tumor protein D52 (TPD52)
- Target
- TPD52
- Molecular classification
- Other, Coiled-coil motif protein
01
Overview
Tumor protein D52 is a member of a conserved protein family with a coiled-coil motif, implicated in vesicle-mediated transport, cell proliferation, and cancer cell metabolism. It interacts with AMPKα, inhibiting its activity and altering energy homeostasis, which promotes tumor development. TPD52 is frequently amplified and overexpressed in breast, prostate, and other cancers, and is considered a potential molecular target as well as a prognostic biomarker for cancer outcomes. TPD52 is distinct from classic receptors, enzymes, or channels; instead, it serves as a regulatory protein impacting cell division, metabolic signaling, and potentially vesicle trafficking in cancer cells.
- Other names
- D52hD52N8LProtein N8PC-1PrLZtumor protein D52prostate and colon associated proteinprostate leucine zipper
02
Mechanism of action
TPD52 overexpression inhibits AMPKα kinase activity, affecting cellular metabolism and potentially supporting tumor growth.
03
Biological functions
Cell proliferationCancer cell metabolism (modulates AMPKα activity)B cell differentiationProtein homodimerization and heterodimerization
04
Disease associations
Cancer (especially breast, prostate, and other solid tumors)Chromosome 8Q21.11 Deletion Syndrome
05
Safety considerations
Targeting TPD52 in cancer therapy may affect normal cell metabolic regulation and immune cell differentiation (data still emerging)Specific therapeutic risks are not well characterized
06
Biomarkers
TPD52 overexpression is a negative prognostic biomarker in breast cancer and other cancers, correlating with poor survival
Beyond the preview
Go deeper on Tumor protein D52 (TPD52).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Tumor protein D52 (TPD52).