Tumor protein D52-like 1 (TPD52L1)

Tumor protein D52-like 1 (TPD52L1) is a member of the tumor protein D52-like gene family, characterized by coiled-coil domains that enable protein-protein interactions, forming both homomers and heteromers. It is implicated in **cell proliferation** and **calcium signaling** and interacts specifically with mitogen-activated protein kinase kinase kinase 5 (**MAP3K5/ASK1**), thereby promoting ASK1-induced apoptosis. Alternative splicing variants include isoforms capable of interacting with 14-3-3 proteins, suggesting a role as a signaling intermediary and possible vesicle trafficking regulation. TPD52L1 is overexpressed in some cancers, notably **breast cancer**, and is considered a potential biomarker. No approved drugs directly target TPD52L1, and while its dysfunction or altered expression is clearly associated with malignant transformation, it is not classified as a typical receptor, enzyme, transporter, or ion channel

Other names

D53hD53TPD53HD53MGC8556LOC681676TPD52Ltumour protein D52-like 1

If targeted: Potential mechanisms might include inhibition of cell proliferation or disruption of calcium-mediated signaling or apoptosis modulation, but currently there are no clinically approved drugs acting directly on TPD52L1