Tumor Protein p53 (Mutant) (mutant p53)

Mutant p53 refers to tumor protein p53 with mutations, most commonly missense mutations in the DNA-binding domain. These mutations lead to loss of normal tumor suppressor functions, such as cell cycle arrest and apoptosis, and often confer new oncogenic gain-of-function properties, including promoting tumor progression, metastasis, angiogenesis, and metabolic reprogramming. Mutant p53 is a major therapeutic target in cancer.

Other names

mutp53mutant TP53p53 mutantmutant p53 protein

Varies depending on the specific mutant p53 and therapeutic approach; strategies include restoring wild-type p53 function, inhibiting mutant p53 gain-of-function activities, or targeting downstream pathways affected by mutant p53.