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Target intelligence / Profile preview
Tumor protein p53 mRNA (TP53 mRNA)
- Target
- TP53 mRNA
- Molecular classification
- mRNA, Transcription factor
01
Overview
TP53 mRNA is the messenger RNA transcript produced from the human TP53 gene, which encodes the tumor suppressor protein p53. This gene and its product play a central role in regulating cell cycle arrest, apoptosis, DNA repair, and genomic stability. Delivery of exogenous wild-type TP53 mRNA into cancer cells lacking functional endogenous p53 induces dose-dependent cytotoxicity via apoptosis/cell cycle arrest.
- Other names
- p53 mRNATP53 messenger RNA
02
Mechanism of action
Restoration of wild-type p53 function via mRNA delivery to induce apoptosis/cell cycle arrest.
03
Biological functions
Cell cycle regulationApoptosis inductionDNA repairGenomic stabilityRegulation of gene expression
04
Disease associations
Cancer
05
Safety considerations
Off-target effects of mRNA deliveryImmunogenicity of mRNAPotential for uncontrolled cell death
06
Biomarkers
TP53 mRNA expression levelsp53 protein levelsMutations in TP53 gene
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