Tumor Protein p53 Y220C Mutant (p53 Y220C)

Tumor protein p53, encoded by the TP53 gene, is a critical tumor suppressor that regulates cell division and prevents uncontrolled cell proliferation. It acts as a transcription factor, binding to DNA and activating genes involved in DNA repair, cell cycle arrest, apoptosis (programmed cell death), and other protective cellular responses. The Y220C mutation is a substitution of tyrosine with cysteine at position 220 within the DNA-binding domain. This mutation creates a hydrophobic cavity that destabilizes the protein, impairing DNA binding and tumor suppression. The unique surface cavity created by Y220C provides an opportunity for targeted drug design: small molecules can bind this crevice to stabilize mutant p53’s structure.

Other names

TP53 Y220Cp53-Y220CY220C p53p53 with Y220C mutation

Small molecule stabilization of mutant protein structure.