Tumor protein p63 regulated gene 1-like protein (TPRG1L)

Tumor protein p63 regulated gene 1-like protein (TPRG1L, also known as Mover or FAM79A) is a vertebrate-specific, non-transmembrane presynaptic protein. It regulates synaptic transmission by decreasing the calcium sensitivity of neurotransmitter release, thereby modulating release probability at synapses[1][2]. TPRG1L localizes to presynaptic terminals and shows region- and terminal-specific distribution within the brain: for example, it is enriched in excitatory mossy fiber terminals in the hippocampus but absent from inhibitory synapses, whereas it is found in inhibitory terminals in the cerebellar cortex[2]. In astrocytes, TPRG1L (Mover) is a lipid droplet coat protein that can drive lipid droplet accumulation, suggesting a dual role in both synaptic transmission and regulation of lipid metabolism in glial cells[3]. TPRG1L enables calmodulin and identical protein binding, participates in the regulation of glutamatergic synaptic transmission, and may interact with or modulate the calcineurin-NFAT signaling cascade[1][4][2][5]. There are no reports of direct drug interactions, biomarker utility, or significant safety concerns related to TPRG1L at present. This entry follows field conventions for biomolecular target annotation. Please note that TPRG1L is not considered a classical therapeutic target such as a receptor, transporter, or enzyme, but may have future research interest in neurological disease mechanisms due to its involvement in synaptic and lipid pathways[1][2][3].

Other names

MoverFAM79AH-MOVERFLJ21811RP11-46F15.3SVAP30TPRGLh-MoverMossy fiber terminal-associated vertebrate-specific presynaptic protein