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Target intelligence / Profile preview
Tumor protein p73 (TP73)
- Target
- TP73
- Molecular classification
- Transcription factor, P53 family
01
Overview
Tumor protein p73 (TP73) is a member of the p53 family of transcription factors, playing a critical role in regulating cellular responses to stress, cell cycle control, apoptosis, and development. It produces several isoforms, notably TAp73 (tumor suppressive) and ΔNp73 (oncogenic), with the balance between these isoforms crucial for tumor suppression versus oncogenic potential. TP73 is rarely mutated in cancers, but its dysregulation contributes to tumorigenesis. It interacts with various proteins and participates in intrinsic apoptotic signaling pathways.
- Other names
- p73Tumor protein p73 isoform TAp73Tumor protein p73 isoform ΔNp73
02
Mechanism of action
Modulation of TAp73/ΔNp73 isoform balance; activation of TAp73
03
Biological functions
Cell cycle controlApoptosis inductionDevelopmental processesCell cycle progressionEmbryonic developmentTissue homeostasisNeurodevelopmentNeurodifferentiationMulticiliogenesisImmune regulationMetabolism regulation
04
Disease associations
Cancer
05
Safety considerations
Off-target effects due to similarity to p53 and p63Potential for developmental defects if targeted during embryogenesisComplex isoform regulation making therapeutic intervention challenging
06
Biomarkers
TAp73/ΔNp73 ratioTP73 expression levels
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