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Target intelligence / Profile preview
Tumor-Specific Immunoglobulin Idiotype Antigen (Idiotype)
- Target
- Idiotype
- Molecular classification
- Immunoglobulin, B-cell receptor
01
Overview
The tumor-specific immunoglobulin idiotype antigen refers to the unique set of antigenic determinants found in the variable regions of immunoglobulins expressed on the surface of malignant B cells. It serves as a highly specific marker for that particular cancer clone and is a target for personalized cancer vaccines or antibody therapies.
- Other names
- IdTumor-specific idiotypeB-cell receptor idiotypeBCR idiotype
02
Mechanism of action
Monoclonal anti-idiotype antibodies induce tumor regression; active vaccination with patient-specific Id proteins induces polyclonal immune responses.
03
Biological functions
Antigen recognitionB-cell receptor signalingTumor marker
04
Disease associations
CancerB-cell lymphoma
05
Safety considerations
Tumor escape via Ig gene mutationToxicity related to vaccine adjuvants
06
Interacting drugs
Anti-idiotype antibodies
1 more in the full profile.
07
Biomarkers
Idiotype protein expression on tumor cells
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