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Target intelligence / Profile preview
Tumor-Specific Mutant Antigens (Neoantigens)
- Target
- Neoantigens
- Molecular classification
- Peptide, Protein, Antigen
01
Overview
Tumor-specific mutant antigens/neoantigens represent highly promising targets for personalized cancer immunotherapy due to their exclusive expression on malignant tissue resulting from unique genetic alterations within tumors. Their identification enables tailored therapeutic strategies aimed at maximizing anti-tumoral immunity while minimizing off-target effects on healthy tissue.
- Other names
- TSAsNeoepitopes
02
Mechanism of action
Stimulate and expand neoantigen-reactive T cells, block immune checkpoints to enhance T cell activity against tumor cells expressing neoantigens, engineer T cells to target neoantigens.
03
Biological functions
Antigen presentationT cell activationImmune response
04
Disease associations
Cancer
05
Safety considerations
Off-target toxicityPatient-specific nature requires personalized approachesLimited number of validated targetable neoepitopes
06
Interacting drugs
Checkpoint inhibitors
2 more in the full profile.
07
Biomarkers
Mutational burdenNeoantigen-specific T cell responsesMHC expression
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