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Target intelligence / Profile preview
Tumor Stroma
- Molecular classification
- Other
01
Overview
The tumor stroma refers to the non-malignant supportive tissue surrounding and infiltrating tumors, including fibroblasts, immune cells, blood vessels, and extracellular matrix. Targeting the tumor stroma with alpha particle emission is an emerging strategy in cancer therapy to disrupt the tumor microenvironment and inhibit tumor growth and metastasis.
- Other names
- Cancer-associated fibroblastsTumor vasculatureExtracellular matrixTumor microenvironment
02
Mechanism of action
Delivery of cytotoxic α-particle emitters via specific ligands binding stromal components, leading to irreparable DNA damage and cell death.
03
Biological functions
Cell survivalCell proliferationAngiogenesisImmune modulationExtracellular matrix organizationDrug resistance
04
Disease associations
CancerMetastasis
05
Safety considerations
Off-target toxicity to healthy tissuePotential for resistance developmentDelivery challenges to the tumor stromaHematological toxicity due to systemic exposure
06
Interacting drugs
Radium-223 dichloride
1 more in the full profile.
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