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Tumor Suppressor Candidate 2
- Molecular classification
- Tumor Suppressor
01
Overview
Tumor Suppressor Candidate 2 (TUSC2) is a protein encoded by the TUSC2 gene, located on human chromosome 3p21.3. It functions as a tumor suppressor and plays critical roles in regulating cell growth, apoptosis, immune function, and mitochondrial calcium homeostasis. Loss of TUSC2 is associated with increased risk of cancer and autoimmune diseases, as well as premature aging phenotypes. TUSC2 gene therapy has been tested clinically for non-small cell lung cancer.
- Other names
- TUSC2
02
Mechanism of action
Induction of apoptosis via intrinsic mitochondrial-dependent pathways involving Apaf-1 activation; G1 cell cycle arrest
03
Biological functions
Tumor suppressionInhibition of cell proliferationPromotion of apoptosisImmune regulationRegulation of mitochondrial calcium homeostasis
04
Disease associations
CancerPremature agingSporadic Alzheimer’s diseaseAutoimmune diseases
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