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Target intelligence / Profile preview
Tumor suppressor candidate 2 protein (TUSC2)
- Target
- TUSC2
- Molecular classification
- Tumor Suppressor Protein, Mitochondrial Protein, Ca2+/myristoyl switch-like protein
01
Overview
TUSC2 is a mitochondrial tumor suppressor protein that induces G1 cell cycle arrest and promotes apoptosis. It also regulates mitochondrial calcium homeostasis, modulates oxidative stress, and influences kinase activity. Loss or downregulation of TUSC2 is associated with various cancers, particularly lung cancer and mesothelioma. Therapeutic strategies involve restoring TUSC2 expression through nanoparticle-mediated delivery.
- Other names
- FUS1LGCCPDAP2C3orf11PAP
02
Mechanism of action
Nanoparticle-mediated delivery of TUSC2 to restore its expression and function as a tumor suppressor.
03
Biological functions
Tumor suppressionRegulation of apoptosisCell cycle regulationRegulation of mitochondrial calcium homeostasisModulation of oxidative stressRegulation of gene expression
04
Disease associations
CancerLung CancerMalignant Pleural Mesothelioma
05
Safety considerations
Potential off-target effects of nanoparticle deliveryImmunogenicity of TUSC2 protein
06
Interacting drugs
Erlotinib
07
Biomarkers
TUSC2 mRNA expression levelTUSC2 protein expression level
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