Tumor suppressor candidate 8 (TUSC8)

TUSC8 is a long non-coding RNA identified as a tumor suppressor candidate and is significantly down-regulated in a range of human cancers, including breast cancer, osteosarcoma, and cervical cancer. It mediates anti-tumor effects predominantly by acting as a competitive endogenous RNA that binds and sequesters oncogenic microRNAs, thereby promoting the expression of a range of tumor suppressor proteins (such as MYLIP, EHD2, and PTEN). The reduction of TUSC8 expression is associated with increased tumor cell proliferation, migration, invasion, and EMT, as well as poorer clinical outcomes. While TUSC8 itself is not a typical druggable target, it is studied as a prognostic biomarker and as a potential indirect therapeutic target through modulation of its regulatory axis in cancer signaling.

Other names

LINC01071XLOC_010588Tumor suppressor candidate 8

Not applicable for drugs, as TUSC8 is not a direct pharmacological target. Functionally, it acts by sequestering oncogenic microRNAs, thereby regulating expression of tumor suppressors or oncogenes (e.g., MYLIP, EHD2, PTEN, MDM2)