Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Tumor Suppressor p53 Protein (p53)
- Target
- p53
- Molecular classification
- Transcription factor
01
Overview
The tumor suppressor p53 protein, encoded by the TP53 gene, is a critical transcription factor that maintains genomic stability and prevents cancer formation. It acts as a sequence-specific transcription factor, inducing growth arrest, apoptosis, or senescence depending on cellular stress. p53 is a modular protein with structured domains (DNA-binding, oligomerization) and unstructured regions at N-/C-terminals. Loss or mutation of functional p53 leads to unchecked cell division, a hallmark event in cancer development.
- Other names
- TP53Transformation-related protein 53Cellular tumor antigen p53
02
Mechanism of action
Activation of target genes involved in cell cycle arrest, DNA repair, apoptosis, and senescence.
03
Biological functions
Cell cycle regulationDNA repairApoptosisSenescenceTranscriptional regulationGenome integrity maintenance
04
Disease associations
Cancer
05
Safety considerations
Loss of function mutations leading to cancerGain of function mutations promoting aggressive cancer phenotypesTherapeutic resistance due to p53 mutationsOff-target effects of p53-targeting therapies
06
Biomarkers
p53 mutation statusp53 expression levels
Beyond the preview
Go deeper on Tumor Suppressor p53 Protein (p53).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Tumor Suppressor p53 Protein (p53).