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Tumor Tissue (targeted by Yttrium-90 microspheres) (N/A)
- Target
- N/A
- Molecular classification
- Tissue, Tumor
01
Overview
Tumor tissue, primarily in the liver, that is selectively irradiated using localized beta-radiation from yttrium-90 (Y-90)-labeled microspheres. This approach, known as radioembolization or selective internal radiation therapy (SIRT), delivers high doses of radiation directly to tumors via preferential lodging of the microspheres in the hypervascularized tumor capillaries, while sparing surrounding healthy tissue. This is achieved through arterial injection of Y-90 microspheres rather than molecular targeting.
- Other names
- Hepatic TumorsLiver TumorsTumor VasculatureY-90 Microsphere Target
02
Mechanism of action
Localized beta-radiation induced DNA damage leading to cell death in tumor tissue.
03
Biological functions
Cell Proliferation (dysregulated)Angiogenesis (dysregulated)Metastasis
04
Disease associations
CancerHepatocellular Carcinoma (HCC)Metastatic Colorectal Cancer
05
Safety considerations
Radiation-induced liver damageBiliary injuryGastrointestinal ulcerationNon-target embolizationPulmonary complications (radiation pneumonitis)FatigueNauseaAbdominal pain
06
Interacting drugs
Yttrium-90-labeled microspheres (TheraSphere®)
2 more in the full profile.
07
Biomarkers
Tumor sizeTumor vascularityLiver function testsLung shunt fraction (for Y-90 dosimetry)Response Evaluation Criteria in Solid Tumors (RECIST)
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