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Tumor Tissue via Local Beta-Radiation Emission
- Molecular classification
- Radioactive isotopes, Radiopharmaceuticals
01
Overview
Local beta-radiation emission targets tumor tissues by delivering therapeutic doses of ionizing radiation precisely within malignant growths, minimizing collateral damage. This is achieved through the selection of appropriate radioisotopes, delivery methods (systemic or intratumoral), and molecular targeting strategies that enhance selectivity for tumor cells. The beta particles emitted cause localized DNA damage, leading to cell death.
- Other names
- Beta-emitting radionuclide therapyRadioisotope therapyTargeted radionuclide therapyIntratumoral injection of radioactive particlesSystemic delivery of radiopharmaceuticals
02
Mechanism of action
Localized emission of beta particles causing DNA damage and cell death in tumor cells and surrounding tissue.
03
Biological functions
DNA damageCell deathTumor ablation
04
Disease associations
Cancer
05
Safety considerations
MyelosuppressionOff-target toxicityRadiation-induced damage to normal tissuesInjection site leakageRisk of secondary malignancies
06
Interacting drugs
Yttrium‑90 (^90Y) microspheres
4 more in the full profile.
07
Biomarkers
Tumor sizeTumor locationExpression of target antigens (for targeted therapies)Bone marrow reserve (platelet count, neutrophil count)Kidney function
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