Tumor Tissue via Localized Beta Radiation

Localized beta radiation therapy targets tumor tissue by delivering beta-emitting radionuclides directly to or near the tumor site. The emitted beta particles cause DNA damage, leading to cell cycle arrest and apoptosis. Selectivity is achieved through carrier molecules that bind to tumor-specific receptors. A key advantage is the cross-fire effect, but potential off-target toxicity due to the long particle range is a major limitation.

Other names

Localized Beta Radiation TherapyBeta Radiation for Tumor TreatmentRadionuclide Therapy for CancerTargeted Beta Therapy

Localized beta radiation therapy delivers beta-emitting radionuclides to or near the tumor site. Beta particles cause ionization and excitation in cellular components, particularly DNA, leading to direct and indirect DNA damage, cell cycle arrest, and apoptosis. The cross-fire effect irradiates multiple adjacent cancer cells.