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Target intelligence / Profile preview
Tumor Vascular Endothelium (TECs)
- Target
- TECs
- Molecular classification
- Cell, Endothelial cell, Vascular endothelium
01
Overview
The tumor vascular endothelium comprises morphologically and functionally distinct endothelial cells critical for cancer progression via disordered angiogenesis, increased permeability/leakiness, facilitation of metastasis, immune modulation, and therapy resistance—all driven predominantly by aberrant signaling pathways such as those involving VEGF-A.
- Other names
- Tumor Endothelial CellsTECsTumor-associated endothelial cells
02
Mechanism of action
Inhibition of angiogenesis, normalization of existing vasculature, enhancement of chemotherapy delivery
03
Biological functions
AngiogenesisRegulation of blood flowNutrient and oxygen transportLeukocyte traffickingImmune modulationExtracellular matrix remodeling
04
Disease associations
Cancer progressionMetastasisDrug resistance
05
Safety considerations
Off-target effects on normal vasculatureDevelopment of resistance to antiangiogenic therapiesCompromised wound healingIncreased risk of thrombosis
06
Interacting drugs
VEGF inhibitors
3 more in the full profile.
07
Biomarkers
CD31 (PECAM1)CD105VEGFR1VEGFR2VEGF-A
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