Target intelligence / Profile preview

Tumor Vasculature (None)

Target: None
Molecular classification: Other

Overview

Tumor vasculature refers to the network of blood vessels that supply nutrients and oxygen to tumor tissues. Unlike normal vasculature, tumor blood vessels are structurally and functionally abnormal, characterized by disorganized architecture, irregular branching, high permeability, and poor perfusion. These abnormalities arise from an imbalance between pro-angiogenic and anti-angiogenic signals within the tumor microenvironment.

Mechanism of action

Antiangiogenic agents inhibit new blood vessel formation; vascular disrupting agents destroy existing abnormal vessels; vasoactive agents temporarily normalize or alter vascular permeability.

Biological functions

Supplies nutrients/oxygenRemoves wasteModulates immunityFacilitating metastasis

Disease associations

Cancer

Safety considerations

Resistance mechanisms exist; some patients do not respond well to monotherapies targeting angiogenesis.Improving selectivity for tumoral versus normal endothelium.

Interacting drugs

VEGF inhibitors

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