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Target intelligence / Profile preview
Tumor Vasculature Endothelial Cells (TECs)
- Target
- TECs
- Molecular classification
- Cell, Endothelial Cell
01
Overview
Tumor vasculature endothelial cells are specialized endothelial cells lining the blood vessels within tumors. They exhibit structural abnormalities, distinct molecular signatures, and functional differences compared to normal endothelial cells. TECs play a crucial role in tumor angiogenesis, nutrient supply, and metastasis, making them attractive targets for anti-cancer therapies.
- Other names
- Tumor Endothelial CellsTumor-Associated Endothelial CellsAngiogenic Endothelial Cells
02
Mechanism of action
Disruption of tumor blood supply, inhibition of angiogenesis, targeting of specific TEC markers
03
Biological functions
AngiogenesisVascular permeabilityNutrient deliveryMetastasisDrug resistanceImmune modulation
04
Disease associations
CancerTumor growthMetastasisAngiogenesis-dependent diseases
05
Safety considerations
Off-target effects on normal vasculatureDevelopment of resistanceHeterogeneity of TECsPotential for promoting alternative angiogenic pathwaysSide effects associated with anti-angiogenic therapies
06
Interacting drugs
Anti-VEGF therapies (e.g., Bevacizumab)
6 more in the full profile.
07
Biomarkers
Circulating TEC levelsExpression of VEGFR2Expression of PDGFRβExpression of TIE2 receptorExpression of Integrins (*α*v integrins)Expression of Aminopeptidase N/AExpression of NG2 proteoglycanExpression of MMP2/MMP9 proteases
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