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Target intelligence / Profile preview
Tumour Necrosis Factor Ligand Superfamily Member 13 (TNFSF13)
- Target
- TNFSF13
- Molecular classification
- Cytokine, Tumor necrosis factor (TNF) ligand family
01
Overview
APRIL/TNFSF13 is a cytokine belonging to the tumor necrosis factor superfamily that plays a crucial role in B cell development, particularly in supporting the long-term survival of plasma cells in the bone marrow. It interacts primarily with BCMA and TACI, and in vitro studies suggest it can also induce apoptosis via other receptors. APRIL is implicated in various diseases, including cancer and autoimmune conditions.
- Other names
- APRILCD256TALL2TALL-2TRDL1TRDL-1ZTNF2UNQ383/PRO715TNLG7B
02
Mechanism of action
APRIL binds to receptors BCMA and TACI to modulate B cell survival and proliferation. It may also interact with FAS/TNFRSF6 and HVEM/TNFRSF14 under certain conditions to induce apoptosis.
03
Biological functions
B cell developmentPlasma cell survivalApoptosis inductionRegulation of tumor cell growthImmune responseHumoral immunity maintenance
04
Disease associations
CancerAutoimmune conditionsArthritis
05
Biomarkers
Onco-inflammatory marker in gliomas
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