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Target intelligence / Profile preview
Tumour Necrosis Factor Ligand Superfamily Member 14 (TNFSF14)
- Target
- TNFSF14
- Molecular classification
- Cytokine, Tumor Necrosis Factor Superfamily Ligand
01
Overview
Tumour necrosis factor ligand superfamily member 14 (TNFSF14), commonly known as LIGHT, is a secreted cytokine belonging to the tumor necrosis factor (TNF) superfamily. It plays a significant role in immune regulation and inflammation. It can deliver costimulatory signals to T cells, leading to their proliferation and interferon-gamma production. TNFSF14 has been explored as an immunotherapeutic target for cancer due to its ability to enhance anti-tumor immune responses. Its involvement in inflammatory diseases makes it relevant for research into autoimmune disorders, cardiovascular disease, fibrosis, and cancer.
- Other names
- LIGHTCD258Herpesvirus entry mediator ligand
02
Mechanism of action
TNFSF14 (LIGHT) binds to its receptors (HVEM, LTBR, Decoy receptor 3) to modulate immune responses and apoptosis.
03
Biological functions
Immune ActivationCostimulatory molecule for lymphoid cell activationT cell proliferationIFN-gamma productionApoptosis RegulationVascular Normalization
04
Disease associations
AtherosclerosisRenal FibrosisEosinophilic EsophagitisCancerInflammatory DiseasesAutoimmune DisordersCardiovascular DiseaseFibrosis
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