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Target intelligence / Profile preview
Tumour suppressor protein p53 (TP53)
- Target
- TP53
- Molecular classification
- Transcription factor, Tumor suppressor
01
Overview
TP53 encodes the tumor suppressor protein p53, a transcription factor that regulates cell division and prevents uncontrolled cell proliferation. It plays a central role in maintaining genomic stability by responding to cellular stresses, inducing cell cycle arrest, apoptosis, senescence, or DNA repair. Mutations in TP53 are the most common genetic alterations in human cancers, leading to loss-of-function or gain-of-function effects that promote tumor development.
- Other names
- p53Tumor protein p53
02
Mechanism of action
Restoration of p53 function is a therapeutic goal; current strategies focus on immunotherapeutic approaches targeting mutant p53 peptides.
03
Biological functions
Cell cycle regulationApoptosisSenescenceDNA repairRegulation of gene expression
04
Disease associations
CancerLi-Fraumeni syndrome
05
Safety considerations
Restoring p53 function without causing off-target effects is a significant challenge.Gain-of-function mutations can complicate therapeutic strategies.
06
Biomarkers
TP53 mutations are prognostic and predictive biomarkers in various cancers.
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