Tunica Intima Endothelial Receptor Tyrosine Kinase 2 (Tie2)

Tunica intima endothelial receptor tyrosine kinase 2 (Tie2) is an endothelial-specific receptor tyrosine kinase crucial for angiogenesis. Ligands Angiopoietin-1 (Ang1) and Angiopoietin-2 (Ang2) regulate vascular quiescence versus remodeling by modulating interactions between endothelial cells and their environment. Tie2 signaling maintains blood vessel integrity by promoting endothelial cell survival, regulating vascular permeability and modulating inflammatory responses. Altered expression or function of Tie2/angiopoietins contributes to abnormal angiogenesis or increased plaque vulnerability in atherosclerosis in pathological states like cancer or diabetes.

Other names

CD202bTEKTunica interna endothelial cell kinase 2

Agonist or antagonist binding to the extracellular domain, modulating tyrosine kinase activity and downstream signaling pathways related to vascular stability and permeability.