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Turkey herpesvirus antigen (HVT antigen)

Target: HVT antigen
Molecular classification: Other (Viral protein, Antigen)

Overview

Turkey herpesvirus antigens are proteins encoded by the genome of turkey herpesvirus (HVT, Marek’s disease virus serotype 3), an alphaherpesvirus used primarily as a live vaccine in poultry to prevent Marek’s disease. HVT antigens induce robust immune responses and are not pathogenic, making them ideal for prophylactic vaccination in poultry. The genome of HVT encodes homologues to various herpesvirus proteins but lacks several virulence-associated genes present in oncogenic Marek’s disease viruses, contributing to its safety and efficacy in vaccination programs. The term "Turkey herpesvirus antigens" is generic and nonspecific; for structured biomedical information, identification of specific viral antigens (e.g., glycoproteins or envelope proteins) would be required.

Other names: Turkey herpesvirus antigenHVT antigenMarek’s disease virus serotype 3 antigenHVT proteinHVT viral protein

Mechanism of action

Induction of immune response (vaccines using HVT antigens trigger humoral and cellular immunity)

Biological functions

Immune response (induction of immune responses; basis for vaccine development)

Disease associations

Infection (protective immunogen against avian herpesvirus infections, especially Marek’s disease in poultry)

Safety considerations

Vaccine safety in target species (attenuated HVT used as a vaccine is generally safe but could have limited recombination risk; HVT itself is non-pathogenic to chickens and turkeys)

Interacting drugs

None (no conventional drugs; interacts with vaccines, e.g., live attenuated vaccines)

Biomarkers

Antibody titers against HVT antigen (for monitoring vaccination status or immune response)

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