Turmeric anti-inflammatory action

Curcumin is a polyphenolic compound derived from the spice turmeric (Curcuma longa). It is not a classical therapeutic target, but a small molecule that exerts pleiotropic anti-inflammatory effects by modulating multiple molecular signaling pathways including the inhibition of nuclear factor kappa-B (NF-κB), mitogen-activated protein kinases (MAPK), the Janus kinase-signal transducer and activator of transcription pathway (JAK-STAT), and the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome[1][2][3][4]. Curcumin also inhibits enzymes like cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), reduces pro-inflammatory cytokine production, and displays antioxidant activity[3][6][7]. As such, "Turmeric anti-inflammatory action" does not correspond to a singular protein or defined target but describes the broad pharmacological actions of curcumin.

Other names

Turmeric active constituentDiferuloylmethane

Inhibition of NF-κB pathway, Inhibition of MAPK/ERK pathway, Inhibition/modulation of JAK-STAT signaling, Suppression of COX-2 and iNOS expression, Direct scavenging of reactive oxygen species, Modulation of NLRP3 inflammasome activation, Ligand/modulator of PPAR-γ[1][2][3][4][6]