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TWIK-related acid-sensitive potassium channel 1 (TASK-1)
- Target
- TASK-1
- Molecular classification
- Potassium channel, Two-pore domain potassium channel (K2P), Ion channel
01
Overview
TASK-1 (TWIK-related acid-sensitive potassium channel 1) is a member of the two-pore domain potassium channel (K2P) family, encoded by the KCNK3 gene. It contributes to background potassium currents, setting the resting membrane potential in excitable cells. It is regulated by extracellular pH, hypoxia, and neurotransmitters. Dysfunction is linked to pulmonary arterial hypertension and potential arrhythmogenic effects. Pharmacologic inhibition has been explored for antiarrhythmic therapy.
- Other names
- K2P3.1KCNK3
02
Mechanism of action
Inhibition of potassium efflux, modulation of membrane potential
03
Biological functions
Regulation of resting membrane potentialRegulation of vascular toneRegulation of neuronal excitabilityPotassium transport
04
Disease associations
Pulmonary arterial hypertension (PAH)Cardiac arrhythmia
05
Safety considerations
Potential arrhythmogenic effectsDysregulation of vascular tone
06
Interacting drugs
Anesthetics
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