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Target intelligence / Profile preview
TWIK-related potassium channel 1 (TREK-1)
- Target
- TREK-1
- Molecular classification
- Ion channel, Potassium channel, Two-pore-domain potassium channel (K2P)
01
Overview
TWIK-related potassium channel 1 (TREK-1) is a member of the two-pore-domain potassium (K2P) channel family. It is a potassium leak channel that produces instantaneous and non-inactivating K+ currents. TREK-1 is mechanosensitive and responds to temperature changes, pH shifts, fatty acids, and certain anesthetics. It plays a role in regulating neuronal excitability, pain perception, mood regulation, and cardiovascular function. Inhibition of TREK-1 has been linked to antidepressant-like effects. Dysregulation may contribute to arrhythmias such as atrial fibrillation.
- Other names
- KCNK2TREK1Two pore domain potassium channel subfamily K member 2K2P2.1
02
Mechanism of action
Potassium channel blocker
03
Biological functions
Regulation of neuronal excitabilityPain modulationRegulation of membrane potentialCardiac repolarization
04
Disease associations
PainDepressionAtrial fibrillationNeuroprotection
05
Interacting drugs
Ba²⁺
4 more in the full profile.
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