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Target intelligence / Profile preview
TWIK-related spinal cord potassium channel (TRESK)
- Target
- TRESK
- Molecular classification
- Potassium channel, Two-pore domain potassium channel, Ion channel
01
Overview
TRESK (TWIK-related spinal cord potassium channel), also known as KCNK18 or K2P18.1, is a member of the two-pore domain potassium (K2P) channel family. These "leak" potassium channels maintain the resting membrane potential. TRESK is highly expressed in sensory neurons and immune cells, regulating neuronal excitability and pain perception. Its activity is regulated by intracellular calcium and calcineurin. Mutations in KCNK18 are linked to migraine with aura. Pharmacological modulation is a therapeutic strategy for migraine, neuropathic pain and potentially immune disorders.
- Other names
- KCNK18K2P18.1MGR13TRESK-2TRIK
02
Mechanism of action
Channel activation/inhibition to modulate neuronal excitability and immune cell function
03
Biological functions
Regulation of neuronal excitabilityMaintenance of resting membrane potentialModulation of pain perceptionRegulation of immune cell functionHyperpolarization
04
Disease associations
Migraine with auraNeuropathic painEpilepsy
05
Interacting drugs
Cloxyquin
1 more in the full profile.
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