Two-pore calcium channel 3 pseudogene (TPC3P or TPCN3P (no universally adopted abbreviation since it is a pseudogene; TPC3 is used for the functional gene in other species))

The two-pore calcium channel 3 pseudogene (ENSG00000184115) is the human remnant of an ancestral gene encoding a two-pore channel (TPC3), which is part of a family of intracellular ion channels responsible for calcium release from acidic organelles in many deuterostomes. In humans and other primates, however, this gene contains inactivating mutations such as frameshifts and premature stop codons, rendering it a pseudogene with no protein product or known biological function. Functional TPCs such as TPC1 and TPC2 remain in humans, where they regulate endolysosomal calcium signaling, but TPC3's function is lost in primates. Key clarification: - TPC3 is a true and functional ion channel in other species (e.g. sea urchin, chicken), but in humans ENSG00000184115 is a pseudogene and does not encode an active channel or protein, nor is it considered a therapeutic target. - If you seek information about functional two-pore channels in humans, refer to TPCN1 (two-pore channel 1) or TPCN2 (two-pore channel 2).

Other names

TPC3 pseudogeneTPCN3PTwo-pore channel 3 pseudogeneTPC3P