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Target intelligence / Profile preview
Two-Pore Domain Potassium Channel TREK-1 (TREK-1)
- Target
- TREK-1
- Molecular classification
- Ion channel, Potassium channel, K2P channel, Two-pore domain potassium channel
01
Overview
TREK-1 is a two-pore-domain potassium (K2P) channel that plays a crucial role in maintaining the resting membrane potential and regulating cell excitability, especially within the central nervous system and heart. It is activated by a variety of stimuli including polyunsaturated fatty acids, mechanical stretch, intracellular acidosis, and heat, and inhibited by neurotransmitters that increase intracellular cAMP or activate Gq protein pathways. Altered TREK-1 function has been linked to epilepsy, ischemic injury, and migraine, making it a potential therapeutic target for neurological disorders, pain management, and cardiovascular diseases.
- Other names
- KCNK2Potassium channel subfamily K member 2
02
Mechanism of action
Modulation of neuronal excitability and cardiac function
03
Biological functions
Resting membrane potential maintenanceRegulation of cell excitabilityNeuroprotectionCardiac function modulation
04
Disease associations
EpilepsyIschemic injuryMigrainePainDepressionHeart failureArrhythmias
05
Interacting drugs
Anesthetics
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