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TXNRD1 antisense RNA 1 (TXNRD1-AS1) is a long non-coding RNA transcribed from the strand opposite to the protein-coding TXNRD1 gene. While its precise biological functions are not fully established, it is presumed to play a regulatory role in gene expression, possibly modulating TXNRD1 protein levels via antisense interactions. TXNRD1-AS1 does not encode a protein, has no accepted canonical drug targets, mechanisms, or established disease roles as of current knowledge, and is sometimes incorrectly conflated with the TXNRD1 protein-coding sequence[5]. If you are seeking information about a classic protein therapeutic target, the correct entry would be Thioredoxin reductase 1 (TXNRD1), which is a cytoplasmic enzyme involved in redox regulation and recognized as a bona fide therapeutic target in multiple disease areas including cancer[1][3][4][7]. TXNRD1-AS1 should not be considered equivalent to TXNRD1.
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