Angiotensin II receptor type 1 (AT1R) (AT1R)

The Angiotensin II receptor type 1 (AT1R) is a G protein-coupled receptor that serves as the primary mediator for the physiological and pathological effects of Angiotensin II, the central effector of the renin-angiotensin-aldosterone system (RAAS) (Source: UniProt P30556). Upon activation, AT1R triggers a complex cascade of downstream signaling pathways, including the Gq/11-phospholipase C pathway, which leads to intracellular calcium mobilization and activation of protein kinase C (Source: StatPearls, Angiotensin II Receptor Blockers). These events result in potent vasoconstriction, stimulation of aldosterone release from the adrenal cortex, and promotion of renal sodium reabsorption (Source: NIH, Gene ID 185). Chronic overactivation of AT1R signaling is a major driver of hypertension, cardiac hypertrophy, and renal fibrosis (Source: PubMed, PMID: 25454601). Consequently, AT1R is a major therapeutic target, with Angiotensin II Receptor Blockers (ARBs) widely used to treat cardiovascular and renal diseases by preventing the binding of Angiotensin II to the receptor (Source: PubChem). Clinical management involves monitoring for side effects such as hyperkalemia and hypotension, and the target is strictly avoided during pregnancy due to known teratogenic effects (Source: FDA).

Other names

AGTR1AT1 receptorAngiotensin II type-1 receptorType-1 angiotensin II receptor

Competitive antagonism of the Angiotensin II receptor type 1 (AT1R), preventing the activation of downstream signaling pathways that mediate vasoconstriction and aldosterone secretion.