Type-1 angiotensin II receptor-associated protein (AGTRAP)

Type-1 angiotensin II receptor-associated protein (AGTRAP, also known as ATRAP) is a membrane-associated protein that interacts specifically with the cytoplasmic domain of the type 1 angiotensin II receptor (AT1R). AGTRAP regulates the internalization and signaling of AT1R, attenuating excessive angiotensin II-mediated responses such as vasoconstriction, sodium retention, cellular proliferation, and hypertrophy. It is broadly expressed in the kidney, heart, vasculature, and metabolic tissues, where it acts as a key endogenous modulator of blood pressure, cardiovascular remodeling, renal sodium handling, and metabolic homeostasis[1][2][3][4]. AGTRAP has emerged as a promising therapeutic target in disorders involving AT1R overactivity, including hypertension, cardiovascular disease, and metabolic syndrome[2].

Other names

ATRAPAT1 receptor-associated proteinAngiotensin II type 1 receptor-associated proteinAGTRAPATI receptor-associated protein

Enhancement of AT1R internalization leading to attenuation of angiotensin II (Ang II) signaling; Negative regulation of Ang II-induced downstream signaling (such as p38 MAPK phosphorylation, c-fos activation, and hypertrophic pathways)[1][2]