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Target intelligence / Profile preview
Type 1 Cyclic Nucleotide Phosphodiesterase (PDE1)
- Target
- PDE1
- Molecular classification
- Enzyme, Phosphodiesterase
01
Overview
Type 1 cyclic nucleotide phosphodiesterases (PDE1) are a family of enzymes that catalyze the hydrolysis of cyclic nucleotides, specifically cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), to their corresponding 5′-monophosphates. This activity regulates intracellular concentrations of these second messengers, thereby modulating various signaling pathways and biological responses. PDE1 is unique among mammalian PDEs for being activated by calcium/calmodulin. Dysregulation or altered expression/activity is implicated in several diseases, making it a therapeutic target.
02
Mechanism of action
Inhibition of PDE1, leading to increased cAMP/cGMP levels
03
Biological functions
Signal transductionRegulation of cAMP/cGMP levelsHydrolysis of cyclic nucleotides
04
Disease associations
Cardiovascular diseasesNeurodegenerative disordersCognitive dysfunctionPsychiatric conditionsCancerMetabolic syndromePulmonary hypertensionCardiac hypertrophy
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