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Type 1 Fibroblast Growth Factor Receptor isoform c (FGFR1c)

Target: FGFR1c
Molecular classification: Receptor Tyrosine Kinase

Overview

Type 1 Fibroblast Growth Factor Receptor (FGFR1c) is a receptor tyrosine kinase that plays a crucial role in cell signaling, influencing cell proliferation, differentiation, migration, and survival. As an isoform of FGFR1, FGFR1c exhibits specific ligand-binding properties due to alternative splicing. Dysregulation of FGFR1c is implicated in various cancers and developmental syndromes, making it a promising therapeutic target.

Mechanism of action

Tyrosine kinase inhibition

Biological functions

Cell proliferationDifferentiationMigrationSurvivalDevelopmental patterningSignal transduction

Disease associations

CancerDevelopmental disorders

Interacting drugs

Erdafitinib

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