Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Type 1 Invariant Natural Killer T Cell (iNKT Cell)
- Target
- iNKT Cell
- Molecular classification
- Lymphocyte, T cell subset
01
Overview
Type 1 invariant natural killer T cells (iNKT cells) are a unique subset of lymphocytes that bridge innate and adaptive immunity. They are defined by their expression of an invariant T cell receptor (TCR) α-chain (Vα14-Jα18 in mice and Vα24-Jα18 in humans) paired with a limited set of β-chains. These cells recognize lipid antigens presented by the non-polymorphic MHC class I-like molecule CD1d. Upon activation, iNKT cells rapidly secrete large amounts of cytokines, playing diverse roles in immune regulation, anti-tumor immunity, and inflammatory diseases.
- Other names
- Type I NKT cellInvariant NKT cellClassical NKT cell
02
Mechanism of action
Activation via lipid antigen presentation by CD1d, leading to rapid cytokine secretion and immunomodulation.
03
Biological functions
Immune responseCytokine productionImmunoregulationBridging innate and adaptive immunityNK cell transactivationDendritic cell modulationB cell response influenceMacrophage activity regulation
04
Disease associations
Infectious DiseasesChronic InflammationFibrosisCancerAutoimmune diseases
05
Safety considerations
Potential for cytokine stormExacerbation of autoimmune diseasesImmunopathology in infectious diseasesOff-target effects of iNKT cell activation
06
Interacting drugs
Alpha-galactosylceramide (α-GalCer)
07
Biomarkers
Vα24-Jα18 + Vβ11 (human)Vα14-Jα18 (mouse)CD161/NK markersPLZFT-betGATA3RORγt
Beyond the preview
Go deeper on Type 1 Invariant Natural Killer T Cell (iNKT Cell).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Type 1 Invariant Natural Killer T Cell (iNKT Cell).